Regenerative and Degenerative Biology
Regeneration is the renewal of degenerated or lost cells, tissues or organs within an organism. Such regenerative processes are mainly based on the action of specific stem or progenitor cells that possess the capacity to proliferate and differentiate into the required cell-types. In Dresden the mechanisms of regeneration and stem cell function are studied to understand general principles of cellular and tissue repair with the aim to use this knowledge to develop novel therapies. Diverse strategies for in depth genetic, molecular and cellular analysis are used to dissect fundamental pathways of tissue regeneration. Animals with high regenerative capacities are utilized to understand intrinsic mechanisms of regeneration as models to induce tissue repair also in mammals. Additionally, the controlled expansion and directed differentiation of stem cells towards specific target cell-types is assessed to develop cell replacement strategies for currently incurable diseases.
© Sandoval Guzmán Group
Research Groups
Michael Bachmann
HZDR Tumorimmunology
Catherina G. Becker
TUD CRTD Development and Repair of the Central Nervous System
Michael Brand
TUD CRTD, TUD PoL Development and Regeneration of the Vertebrate Brain
Björn Falkenburger
TUD Medical Campus, DZNE Cell biology of neurodegenerative diseases
© CRTD
Mike Karl
DZNE, TUD CRTD Unraveling mechanisms of neuronal degeneration and regeneration in the retina
Franziska Knopf
TUD CRTD Biology of bone regeneration
Natalia Rodríguez Muela
DZNE, TUD CRTD Selective neuronal vulnerability in neurodegenerative diseases
Tatiana Sandoval Guzmán
TUD PLID, TUD Medical Campus Vertebrate tissue repair and regeneration
Michael Sieweke
TUD CRTD Stem Cell and Macrophage Biology