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Internship Positions 2022

Group (Institute) Research Area
Project Title(s)
Duration in weeks Student Background
Hayder Amin (DZNE) Mathematics, Neurocomputation, Bioengineering, Network Electrophysiology
Computational properties of rates and rhythms in large-scale neuronal networks
12 Computer Science, Mathematics and/or Bioengineering, or similar fields. Fluency in coding with Python or equivalent is essential.
Olaf Bergmann (TUD CRTD) Heart Regeneration
Exploring cardiomyocyte cell cycle activity in mammalian hearts
12 Life Science, Medicine
Michael Brand (TUD CRTD) Genetic Engineering
Development of a near-infrared optogenetic system for Cre/loxP recombination in zebrafish
12 Bioengineering or Life Science
Henrik Bringmann (TUD BIOTEC) Biology, Biomedicine
Impact of sleep loss on skin and immune system function in C. elegans
12 Life Science
Frank Buchholz (TUD Medical Campus) Gene Therapy
Investigating the preexisting immunity of the general population to Cre recombinase
12 Life Science or Medicine
Ünal Coskun (TUD PLID) Metabolism, Lipids, Lipidomics, Lipid-Protein Interactions
Therapeutic antibodies against glycolipids
12 Life Science
Ünal Coskun (TUD PLID) Metabolism, Lipids, Lipidomics, Lipid-Protein Interactions
Direct regulation of AKT signaling by lipids-protein interaction
12 Life Science
Christian Dahmann (TUD Biology) Developmental Biology
How embryos take shape: from genes to cell mechanics
8–12 Life Science
Natalie Dye (TUD PoL) Cell and Developmental Biology, Biophysics
Self-organization in animal morphogenesis: how 3D tissue morphology emerges from dynamic cellular interactions
12 Any is welcome. Those with math/physics/compsci/eng background should be interested in gaining some knowledge in biology and applying their skills to a life science problem. Life science background is also welcomed, especially those with some programming/computer skills.
Björn Falkenburger (TUD Medical Campus) Cell Biology, Parkinson’s Disease
FRET-based biosensors in IPS cell-derived neurons
12 Life Science or Medicine
Maria Fedorova (TUD Medical Campus) Metabolism, Lipids, Lipidomics, Lipid-Protein Interactions
Lipidomics of liver pathologies
12 Life Science
Maria Fedorova (TUD Medical Campus) Metabolism, Lipids, Lipidomics, Lipid-Protein Interactions
Lipidomics of cell death
12 Life Science
Elisabeth Fischer-Friedrich (TUD PoL) Biological Physics/Quantitative Biology
Image analysis of time lapse movies for analysis of mitotic roundness and cell cycle duration in tumor spheroids
12 Life Science, Computer Science, or Physics with a good hand for computers and data evaluation
Benjamin Friedrich (TUD PoL, TUD cfaed) Theoretical Biological Physics
How to build muscle? Mathematical modeling of myofibrillogenesis in muscle cells.
12 Physics, Mathematics, or Computer Science
Hanno Glimm (TUD Medical Campus) Cancer Research
Identification of GPCRs involved in Tumor-initiating cell activation in Pancreatic cancer
12 Life Science
Kaomei Guan (TUD MTZ) Stem Cell Biology, Cardiovascular Research
Induction of iPSC-cardiomyocyte maturation by the combination of microfluidic and electrical stimulation
12 Life Science, Medicine
Nils Kröger (TUD B CUBE) Biophysics, advanced microscopy techniques, genetic engineering
Investigating the role of CapZ in the actin dynamics of C. australis

Investigating the role of CapZ in the actin dynamics of C. australis

Use TIRFM to determine if any movement of CapZ can be seen in C. australis, to demonstrate possible changes in the length/number of actin filaments.

(Possibly) use super-resolution microscopy to obtain higher resolution images showing precise location of CapZ (and ends of actin filaments) – This would require some cloning work to express CapZ as a fusion protein with a suitable fluorophore, or development of a method to introduce a dye into the cell.

 
10 Life Science, Engineering, Physics
Nils Kröger (TUD B CUBE) Bioinformatics, computer sciences, genetic engineering
In silico identification of actin-associated proteins in C. australis

In silico identification of actin-associated proteins in C. australis

Screening of the C. australis genome against known sequences of actin assosciated proteins (profilin, anilin etc.) - This can either be done manually through BLAST, or better yet, can be automated by a student with a good background in programming.

Confirm gene model and express promising targets as FP fusion proteins.

 
10 Life Science, Engineering, Computer Science
Nils Kröger (TUD B CUBE) Biophysics, advanced microscopy techniques, genetic engineering
Investigation of actin structure/dynamics of C. australis via advanced microscopy

Investigation of actin structure/dynamics of C. australis via advanced microscopy

Further work on the structure/dynamics of actin through one or more of the following approaches:

  • Structured illumination microscopy using LifeAct-GFP or ActCb-EmeraldFP expressing C. australis cells.
  • Express ActCb fused to a photoactivatable fluorophore, to perform a photoactivation experiment to monitor actin dynamics.
  • Transform C. australis to express either LifeAct or ActCb fused to a fluorophore suitable for super-resolution microscopy, or develop a method to introduce a photoactivatable dye into cells.
 
 
10 Life Science, Engineering, Physics
James Sáenz (TUD B CUBE) Synthetic biology, membrane biophysics, lipidomics, microbiology, host-pathogen interactions
Exploring the minimal design principles of living membranes
12 Life Science, Engineering, Computer Science, Physics, Mathematics, or Medicine
Bernd Schröder (TUD MTZ) Biochemistry/Cell Biology
Structure-function analysis of protein-protein interactions and protease-substrate pairs [→ Info PDF]
12 Life Science
Michele Solimena (TUD PLID) Bioinformatics
A new -omics landscape of human pancreatic islets in health and diabetes

A new -omics landscape of human pancreatic islets in health and diabetes

Tasks

  • implementation of a database in the RedCap system for the human pancreatic islet biobank of living donors
  • implementation of a graphic display of big data (clinical, physiological and -omics information) from human pancreatic islets of living donors to drive biological discovery and validation

References

  • Solimena et al, Diabetologia 2018
  • Barovic et al, Mol. Metabolism 2019
  • Khamis et al, Mol. Metabolism 2019
  • Wigger et al, Nat. Metabolism 2021
 
 
12
Anna Taubenberger (TUD BIOTEC) Bioengineering, Cancer Research, Biophysics
Studying prostate epithelial – stromal interactions using 3D in vitro models
12 Life Science, Engineering, Physics or Medicine
Attila Tóth (TUD MTZ) Genetics and Protein Biology
Secret of safe sex: analysis of chromosomal proteins that safeguard meiotic recombination
12 Life Science